Braja Sorensen Team December 25, 2020 Worksheet
The quiz is designed as a summative assessment that probes student understanding of the key concepts addressed in the film. The resulting proteins stick together to form long fibers and distort the shape of the red blood cells.
Hhmi sickle cell anemia worksheet. It inhibits the cation transport in red blood cell membrane. Students then had time to work on the case study worksheet before the end of class. It has the potential of cure the disease.
The mutation caused by sickle cell anemia changes the way the molecules of red blood cells bond and form their shape, resulting in elongated patterns which ultimately form the sickle shape. Sickle cell anemia this short animation shows that sickle cell anemia is caused by a single nucleotide change in the hemoglobin gene, which causes an amino acid substitution in the hemoglobin protein from glutamic acid to valine. You may wish to show the film outside of class.
Sickle cell disease 1/2 (50%) sickle cell trait 1/2 (50%) completely normal hemoglobin 0% e. The enhanced resistance of persons with sickle trait to falciparum malaria is substantial. Prezi extensions to mendelian genetics.
In addition, the article has information about the inheritance of sickle cell disease and how it alters hemoglobin. Sickle cell disease (also known as sickle cell anemia) is caused by a mutation in the protein hemoglobin. It is a chemotherapeutic agent.
Sickle cell anemia active reading & worksheet is three pages long. Malaria and sickle cell anemia video guide. The sickle cells also block the flow of blood through vessels, resulting in lung tissue damage that causes acute chest syndrome, pain episodes, stroke and priapism (painful, prolonged erection).
Students then had time to work on the case study worksheet before the end of class. Take the quiz and test your knowledge! Hhmi biointeractive has lots of awesome resources for.
A) subject to changes in mchc: When the blood of patients with sickle cell disease is deoxygenated, blood viscosity increases because of polymerization of hemoglobin s. Students read a passage about the decades of research on sickle cell disease (also known as sickle cell anemia), which was conducted prior to anthony allison’s work.
It increases fetal hemoglobin production. Explain the differences between an individual homozygous for the sickle hemoglobin allele (hbs/hbs) and one who is heterozygous (hba/hbs). Individuals with one sickle cell allele are protected from malaria and do not have sickle cell disease, thus keeping the allele in the population.
It suppresses bone marrow production of sickle hemoglobin. The relation between sickle cell and anemia gains further ground on the fact, that there is a greater incidence of sickle cell in the african lowland populations, where malaria is severe and widespread than among their highland counterparts. How much do you know about sickle cell disease?
After the video, students had time to begin reading a sciencedaily article (alone or in pairs) which provides additional information about the genetic basis of how sickle cell anemia protects from malaria. It also causes damage to the spleen, kidneys and liver. • teachers may discuss with the class how sickle cell disease provides an interesting example of the arbitrary nature of the terms dominance, incomplete dominance and codominance.
Centers for disease control and prevention. If the entire family moves to the lowlands of east africa, four of the five males in the pedigree will have two genetic advantages over the other individuals in the family. Hhmi video on scientific discovery of link between incidence of malaria and sickle cell characters by dr.
E) all of the above are correct Sickle cell disease, at an organismal level, is defined as an autosomal recessive disorder because one copy of hba produces enough normal hemoglobin to prevent anemia. It is believed that sickle cell provides resistance against the malarial parasite.
It describes the incidence of sickle cell disease in africa and the united states. After the video, students had time to begin reading a sciencedaily article (alone or in pairs) which provides additional information about the genetic basis of how sickle cell anemia protects from malaria. Malaria, natural selection, population genetics, red blood cells, sickle cell disease.
Prezi intro to mendelian genetics. The animation illustrates how the mutated hemoglobin proteins can change the shape of red blood cells and ultimately reduce blood flow through the body. People with one sickle cell allele are protected from malaria, but do not have sickle cell disease.
Hydroxyurea is useful in management of sickle cell disease because a. Homozygous, hypothesis, in vitro, in vivo, malaria, mutation, natural selection, pedigree, phenotype, recessive, sickle cell anemia, sickle cell disease, sickling, trait. This allows them to glide.
Hhmi is a science philanthropy whose mission is to advance basic biomedical research and science education for the benefit of humanity. Through a series of questions, students explore how allison’s discovery was made possible by the work of others and how he was able to make the link between sickle cell disease. Take this quiz to find out!